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CD63 antibody [MEM-259] (FITC)

Anti-CD63 antibody [MEM-259] (FITC) used in Flow cytometry (FACS). GTX18235

Cat. No. GTX18235

Reference 9

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 MEM-259

Isotype

 IgG1

Application

 ICC/IF, FACS

Reactivity

 Human
Package
100 test ($399)
See all CD63 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
FACS 20 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension
Not tested in other applications.

Calculated MW

26 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

HPB-ALL T cell line

Purification

Purified by size-exclusion chromatography

Conjugation

Fluorescein isothiocyanate (FITC)

RRID

AB_423141

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD63 , CD63 molecule , LAMP3 , ME491 , MLA1 , OMA81H , TSPAN30

Cellular Localization

Cell membrane,Lysosome membrane,Late endosome membrane,Endosome,Multivesicular body,Melanosome

Background

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]

Database

Research Area

DATA IMAGES

Anti-CD63 antibody [MEM-259] (FITC) used in Flow cytometry (FACS). GTX18235

GTX18235 FACS Image

FACS analysis of peripheral blood lymphocytes from a patient with allergy to bee venom after stimulation with bee venom using GTX18235 CD63 antibody [MEM-259] (FITC).

REFERENCE

Clone Reference

Lanna A et al. Nat Cell Biol 2022; 24 (10):1461-1474 An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory.
Cheng Zhang et al. J Extracell Vesicles 2022; 11 (4):e12209 Plasma extracellular vesicle derived protein profile predicting and monitoring immunotherapeutic outcomes of gastric cancer.
Peng X et al. Biochim Biophys Acta Mol Cell Res 2021; 1868 (1):118857 IKKβ activation promotes amphisome formation and extracellular vesicle secretion in tumor cells.
Lenzini S et al. ACS Nano 2021; 15 (11):17439-17452 Cell-Matrix Interactions Regulate Functional Extracellular Vesicle Secretion from Mesenchymal Stromal Cells.
Huang C.C. et al. Microfluidics and Nanofluidics 2021; 25 A miniaturized, DNA-FET biosensor-based microfluidic system for quantification of two breast cancer biomarkers.
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REVIEW

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Application Reference
Jakhria T et al. J Biol Chem 2014; β2-microglobulin Amyloid Fibrils are Nanoparticles that Disrupt Lysosomal Membrane Protein Trafficking and Inhibit Protein Degradation by Lysosomes.
Application : ICC/IF
Reactivity : Human
Clone Reference
Lanna A et al. Nat Cell Biol 2022; 24 (10):1461-1474 An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory.
Cheng Zhang et al. J Extracell Vesicles 2022; 11 (4):e12209 Plasma extracellular vesicle derived protein profile predicting and monitoring immunotherapeutic outcomes of gastric cancer.
Peng X et al. J Exp Clin Cancer Res 2021; 40 (1):183 LINC00511 drives invasive behavior in hepatocellular carcinoma by regulating exosome secretion and invadopodia formation.
Peng X et al. Biochim Biophys Acta Mol Cell Res 2021; 1868 (1):118857 IKKβ activation promotes amphisome formation and extracellular vesicle secretion in tumor cells.
Lenzini S et al. ACS Nano 2021; 15 (11):17439-17452 Cell-Matrix Interactions Regulate Functional Extracellular Vesicle Secretion from Mesenchymal Stromal Cells.
Huang C.C. et al. Microfluidics and Nanofluidics 2021; 25 A miniaturized, DNA-FET biosensor-based microfluidic system for quantification of two breast cancer biomarkers.
Yang L et al. Mol Cancer 2019; 18 (1):78 Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma.
Raulf N et al. Eur J Cancer 2018; 102:52-68 Annexin A1 regulates EGFR activity and alters EGFR-containing tumour-derived exosomes in head and neck cancers.
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399